Genetics Research Lab-4

Stem Cell And Regenerative Medicine Group

Today, not many malignancies have promising results as potential curative treatment modality. Cure  theoretically requires the total eradication of all malignant cells from the patient's body. Therefore a variety of purging modalities have been applied to the treatment of hematopoietic malignancies in order to deplete residual malignant cells in patients. Many researches are trying to find the magic bullet that will clear the body from malignant cells. Emerging evidence indicates that cancer stem cells(CSC) can be target for the initiation of the some of the hematological malignancies. Combining all these fundamentals with the investigation of identified CSC, will lead to a considerable increase in the understanding of the molecular mechanisms and signaling pathways and are likely to provide key insights into more efficient drug design and therapy.

Purified CSC, will provide a powerful substrate for preclinical testing of the efficacy of newly developed chemotherapeutic agents. Therefore, we will pursue the characterization and identification of CSC. The aim of the project  is to identify the CSC phenotype that initiates the disease, understanding its functional characteristics and exploring the potential effect of some therapeutical options on malignant cells as a powerful treatment modality.

As a leading research institute in Istanbul University Medical Faculty, we serve to the patients from all around Turkey and have such big population of patients. The Institute has very well established research training environment for researchers as well as students.  This project will not only enhance our scientific knowledge also further help us to identify the some of the unknowns about the cancer stem cells.

Deneysel Tıp Araştırma Enstitüsü, Genetik A.D. Vakıf Gureba Cad. Çapa, 34093 -İstanbul

Total resource (BAP): 0,00 TL